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Neratinib augments the lethality of [regorafenib + sildenafil]

L Booth et al., Journal of cellular physiology,  September 2018

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Palbociclib augments Neratinib killing of tumor cells that is further enhanced by HDAC inhibition

L Booth et al., Cancer Biology &Therapy, 5 September 2018

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The CHK1 inhibitor SRA737 synergizes with PARP1 inhibitors to kill carcinoma cells

Laurence Booth, Jane Roberts, Andrew Poklepovic & Paul Dent, Cancer Biology & Therapy, 19 July 2018

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Expansion and Antitumor Cytotoxicity of T-Cells Are Augmented by Substrate-Bound CCL21 and Intercellular Adhesion Molecule 1

Adutler-Lieber et al., Front. Immunol., 11 June 2018

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Valproate augments Niraparib killing of tumor cells

Laurence Booth et al., Cancer biol ther., June 2018

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Protection from  cytomegalovirus viremia following glycoprotein B vaccination is not dependent on neutralizing antibodies

Baraniak et al.,PNAS April 23, 2018 

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The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair

Baranes-Bachar et al., Molecular Cell, Volume 69, Issue 5, 1 March 2018, Pages 866-878.e7

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TP53 is required for BECN1-and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition‏

Santiago Lima et al., Autophagy, Jan 25, 2018

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[Neratinib + Valproate] exposure permanently reduces ERBB1 and RAS expression in 4T1 mammary tumors and enhances M1 macrophage infiltration.

Booth et al., Oncotarget, 26;9(5):6062-6074Dec 2017  

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The levels of mutant K-RAS and mutant N-RAS are rapidly reduced in a Beclin1 / ATG5 -dependent fashion by the irreversible ERBB1/2/4 inhibitor neratinib

Laurence Booth t al., Cancer biology & therapy, volume 19, issue 2, 2018

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Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species

Jane L. Roberts, Andrew Poklepovic and Laurence Booth, Oncotarget, August 2017

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DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV‐1 infection of macrophages

Petra Mlcochova,* , Sarah J Caswell, Ian A Taylor, Greg J Towers & Ravindra K Gupta, The EMBO Journal, October 2017

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Substrate-bound CCL21 and ICAM1 combined with soluble IL-6 collectively augment the expansion of antigen-specific murine CD4+ T cells

Shimrit Adutler-Lieber, et al., Blood Advances Journal, Volume 1, Issue 15, pp 1016-1030, May 13, 2017

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A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages

Petra Mlcochova et al., The EMBO Journal, Volume 36, Issue 2 , pp 129 – 244, January 25, 2017

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PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide

Laurence Booth, Jane L. Roberts, Andrew Poklepovic, Sarah Gordon, Paul Dent, Impactjournals- Oncotarget, Advance Publications 2016, November 2016, changes 5: 9

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Lipopolysaccharide induces proliferation and osteogenic differentiation of adipose-derived mesenchymal stromal cells in vitro via TLR4 activation

Nicole Herzmann, Achim Salamon, Tomas Fiedler and Kirsten Peters, Experimental Cell Research, http://dx.doi.org/10.1016/j.yexcr.2016.11.012

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The commonly used nonionic surfactant Span 80 has RXRα transactivation activity, which likely increases the obesogenic potential of oil dispersants and food emulsifiers

Bowers RR , Temkin AM , Guillette LJ , Baatz JE , Spyropoulos DD; Gen Comp Endocrinol., 2016 Apr . doi:10.1016/j.ygcen.2016.04.029. PMID: 27131391.

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Rationally repurposing Ruxolitinib (Jakafi®) as a solid tumor therapeutic     

Tavallai Mehrad, Booth Laurence, Roberts Jane L, Poklepovic Andrew, Dent Paul ; Frontiers in Oncology ,vol.6,2016      

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Effects of crude oil/dispersant mixture and dispersant components on PPARγ activity in vitro and in vivo: identification of dioctyl sodium sulfosuccinate (DOSS; CAS #577-11-7) as a probable obesogen.

Temkin AM et al.; Environ Health Perspect, 2016, 124:112–119

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 Nexavar/Stivarga and ViagraInteract to Kill Tumor Cells

Tavalla et al., Journal of Cellular Physiology, 2015, 230: 2281–2298

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PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types

Booth L. et al., Journal of Cellular Physiology, May 2015, Volume 230, Issue 5, pages 1115–1127,

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Registered report: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

Evans J. et al., August 2015, eLife 2015;4:e07301. DOI: 10.7554/eLife.07301

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GRP78 / BiP / HSPA5 / Dna K is a universal therapeutic target for human disease

Booth L. et al.; Journal of Cellular Physiology, 2015, 230(7): 1661-76

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Differential regulation of autophagy and cell viability by ceramide species

Nichola Cruickshanks , Jane L Roberts , M Danielle Bareford , Mehrad Tavallai , Andrew Poklepovic , Laurence Booth , Sarah Spiegel , Paul Dent ,Cancer Biology & Therapy  Vol. 16, Iss. 5, 2015

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Variomics screen identifies the reentrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation

Bill A. et al.;  Journal of Biological Chemistry, 2015, 290: 889-903

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High-throughput fluorescence imaging approaches for drug discovery using in vitro and in vivo three-dimensional models

Natalia J Martinez , Steven A Titus , Amanda K Wagner , Anton Simeonov  ,Expert Opinion on Drug Discovery  Vol. 10, Iss. 12, 2015

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Celecoxib enhances [sorafenib + sildenafil] lethality in cancer cells and reverts platinum chemotherapy resistance

Timothy Webb , Jori Carter , Jane L Roberts , Andrew Poklepovic , William P McGuire , Laurence Booth , Paul Dent , Cancer Biology & Therapy  Vol. 16, Iss. 11, 2015

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3,5-Diamino-1,3,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors

Kutz CJ. Et al.; Medicinal Chemistry Communications, 2014, 5, 1863-1870

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Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs

Booth L. et al.; Mol Cancer Ther, October 2014, 13; 2384

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The Cofilin Phosphatase Slingshot Homolog 1 (SSH1) Links NOD1 Signaling to Actin Remodeling

Bielig H. et al.; PLOS Pathogens, 2014, 10, 9.

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Soft/elastic nanopatterned biointerfaces in the service of cell biology

Platzman l. et al.; METHODS IN CELL BIOLOGY; 2014, 119:237-260

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HIV-1 evades innate immune recognition through specific cofactor recruitment.

Rasaiyaah J. et al.; Nature, 2013 Nov 21;503(7476):402-5

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Regulation of Integrin Adhesions by Varying the Density of Substrate-Bound Epidermal Growth Factor

Shahal T. et al.; Biointerphases  ,2012, Volume 7, Issue 1

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