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Cell Viability – Toxicology Assay

Fast and reliable high throughput cytotoxicity assays
Toxicology assay applied for drug toxicity studies in Cancer research

Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs; Booth L. et al.; Mol Cancer Ther, October 2014, 13; 2384

This paper showed that drug combination leads to a better effect on cell death then treatment with each drug separately. Drug A (PDES) inhibition with drug B (OSU-03012) activate the death receptor CD95 and lead to cell death in higher efficiency than each drug separately. The results suggest involvement of ER stress in the drug mechanism of action.

Hermes imaging data obtained at Virginia Commonwealth University, VA, USA.