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Time Lapse Assays

Capture time-dependent events using rapid acquisition rate & accurate localization repeatability

Hermes High content imaging system with environmental control for live cell experiments enables time-lapse imaging to continuously monitor live cell proliferation, morphology and viability, follow dynamic processes and characterize changes of cell populations. Real-time cell analysis can be applied to detect isles of interest within the well and re-visit specific objects to monitor and capture their activity over time.

  • Rapid scanning rate (e.g. 96 locations in less than 2 minutes)
  • 200nm  localization repeatability
  • Microplate does not move along the scanning process, avoiding vibrations to the gentle biological samples and achieving high re-positioning accuracy
  • Multi time point scanning
  • Flexible definition of cycles and intervals
  • Apply real-time cell analysis using rare events automatic detection and follow-up over time with option to select objects for re-visiting

Spheroid growth assay

Multiwell plate view of spheroid growth assay using time lapse experiment of 40h

Live Zebrafish imaging 

Video capture from a live Zebrafish larva imaged in bright field illumination using 10X magnification.

Acquired by Dr Gillian Tomlinson using IDEA Bio-Medical’s Hermes WiScan at the UCL Division of Infection and Immunity, London, UK.

Real time Phagocytosis 

HKTB MDM Denoise: Human monocyte derived macrophages with heat killed M tuberculosis (green|) With thanks to Dr Meera Mehta, UCL Division of Infection & Immunity

C-Elegans live imaging

Live imaging of the nematode Caenorhabditis Elegans acquired with Hermes high content imaging system in bright field and Red fluorescence channel.

Mitochondria in live cells

Mito-tracker labeling to follow the formation of mitochondria clusters in live cells.




Clusters  dynamics

OT-II T-cells (blue) co-cultured with ovalbumin-loaded DCs (green), with cell death marker (red) (propidium iodide). Both clusters and single cells were able to join and leave existing clusters.

Dynamics of clusters of T-cells stimulated by antigen-loaded dendritic cells
Shimrit Adutler-Lieber, Nir Friedman, Benjamin Geiger

Department of Molecular Cell Biology
The Weizmann Institute of Science
Rehovot, Israel

Combine sub-population analysis over time to study cycles of protein expression

Time-lapse imaging of live cells with a fluorescently tagged nuclear protein, followed by analysis of protein expression over time enabled identification of a periodic expression pattern.

Detected living cells were classified into sub-populations based on the level of expression of the tested protein in their nucleus. Image analysis was then performed to quantify the percentage of cells expressing the tested protein above a user-defined intensity threshold.

A periodic expression pattern of the tested protein was revealed using an expression plot over time.

time lapse population analysis HTS


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