Citations- Cell Biology

Golgi screen identifies the RhoGEF Solo as a novel regulator of RhoB and endocytic transport
Cristiana Lungu, Florian Meyer, Marcel Hörning, Jasmin Steudle, Anja Braun, Bettina Noll, David Benz, Felix Fränkle, Simone Schmid, Stephan A. Eisler, Monilola A. Olayioye, December 2022 https://doi.org/10.1111/tra.12880

A novel, dual action chimera comprising DNA methylating agent and near-IR xanthene-cyanine photosensitizer for combined anticancer therapy
Ebaston Thankarajan, Dipak Walunj, Andrii Bazylevich, Chandrashekhar Prasad, Arkadi Hesin, Leonid Patsenker, Gary Gellerman, Photodiagnosis and Photodynamic Therapy, 2022,102722,ISSN 1572-1000, https://doi.org/10.1016/j.pdpdt.2022.102722.

Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability

Dan Sarni, Sonia Barroso, Alon Shtrikman, Michal Irony-Tur Sinai, Yifat S. Oren, Andrés Aguilera, Batsheva Kerem, Cell Reports, Volume 40, Issue 13, 2022, 111397, ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2022.111397.

Oxidative Stress Response in Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells

Waheed, Tawakalitu Okikiola, Olga Hahn, Kaarthik Sridharan, Caroline Mörke, Günter Kamp, and Kirsten Peters. 2022 International Journal of Molecular Sciences 23, no. 21: 13435. https://doi.org/10.3390/ijms232113435

Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress  
Rebecca L Lloyd, Vaclav Urban, Francisco Muñoz-Martínez, Iñigo Ayestaran, John C Thomas, Christelle de Renty, Mark J O’Connor, Josep V Forment, Yaron Galanty, Stephen P Jackson Nucleic Acids Research gkab628; doi: https://doi.org/10.1093/nar/gkab628

Comparative Proteomic and Metabolomic Analysis of Human Osteoblasts, Differentiated from Dental Pulp Stem Cells, Hinted Crucial Signaling Pathways Promoting Osteogenesis. 

Nováková, S.; Danchenko, M.; Okajčeková, T.; Baranovičová, E.; Kováč, A.; Grendár, M.; Beke, G.; Pálešová, J.; Strnádel, J.; Janíčková, M.; Halašová, E.; Škovierová, H. Int. J. Mol. Sci. 2021, 22, 7908. https://doi.org/10.3390/ijms22157908

 Novel combination of isovanillin, curcumin, and harmine (GZ17-6.02) enhances cell death and alters signaling in actinic keratoses cells when compared to individual components and two-component combinations

Bordeaux, Zachary A.Kwatra, Shawn G.Booth, LaurenceDent, Paul  Anti-Cancer Drugs, Volume 34, Number 4, 18 April 2023, pp. 544-550(7) DOI: https://doi.org/10.1097/CAD.0000000000001425

Targeted methylation facilitates DNA double strand breaks and enhances cancer suppression: A DNA intercalating/methylating dual-action chimera Amonafidazene
Dipak Walunj, Ebaston Thankarajan, Chandrashekhar Prasad, Helena Tuchinsky, Simone Baldan, Michael Y. Sherman, Leonid Patsenker, Gary Gellerman, European Journal of Medicinal Chemistry, Volume 225, 2021, 113811, ISSN 0223-5234, https://doi.org/10.1016/j.ejmech.2021.113811.

The GEF-GAP pair Solo and DLC3 balances Rho activity during endocytic transport

C Lungu, F Meyer, M Hörning, J Steudle, A Braun et al., bioRxiv, 2022 bioRxiv preprint doi: https://doi.org/10.1101/2022.03.01.482527

Pericyte derived chemokines amplify neutrophil recruitment across the cerebrovascular endothelial barrier.

Gil E, Venturini C, Stirling D, Turner C, Tezera LB, Ercoli G, Baker T, Best K, Brown JS, Noursadeghi M. Front Immunol. 2022 Jul 28;13:935798. doi: 10.3389/fimmu.2022.935798. PMID: 35967327; PMCID: PMC9371542.

Comparative Proteomic and Metabolomic Analysis of Human Osteoblasts, Differentiated from Dental Pulp Stem Cells, Hinted Crucial Signaling Pathways Promoting Osteogenesis. 

Nováková, S.; Danchenko, M.; Okajčeková, T.; Baranovičová, E.; Kováč, A.; Grendár, M.; Beke, G.; Pálešová, J.; Strnádel, J.; Janíčková, M.; Halašová, E.; Škovierová, H. Int. J. Mol. Sci. 2021, 22, 7908. https://doi.org/10.3390/ijms22157908

The Biocompatibility of Wireless Power Charging System on Human Neural Cells

Henrieta Skovierova 1,*, Miroslav Pavelek 2 , Terezia Okajcekova 3 , Janka Palesova 3 , Jan Strnadel 1 , Pavol Spanik 2 , Erika Halašová 1 and Michal Frivaldsky 2 J. Appl. Sci. 2021, 11, 3611. https://doi.org/10.3390/app11083611

Membrane anchored IL-18 linked to constitutively active TLR4 and CD40 improves human T cell antitumor capacities for adoptive cell therapy

Blokon-Kogan D, Levi-Mann M, Malka-Levy L, et al, Journal for ImmunoTherapy of Cancer  2022;10:e001544. doi: 10.1136/jitc-2020-001544

Cellular responses after (neratinib plus pemetrexed) exposure in NSCLC cells.

Booth, Laurencea; Poklepovic, Andrewb; Hancock, John F.c; Dent, Paula.Anti-Cancer Drugs 34(9):p 1025-1034, October 2023. | DOI: 10.1097/CAD.0000000000001442 

eIF2α integrates proteotoxic signals both from ER and cytoplasm: Hsp70-Bag3 module regulates HRI-dependent phosphorylation of eIF2α

Shivani Patel, Santosh Kumar, Arkadi Hesin, Julia Yaglom, Michael Y. Sherman, bioRxiv 2021.04.13.439701; doi: https://doi.org/10.1101/2021.04.13.439701

Comparative Proteomic and Metabolomic Analysis of Human Osteoblasts, Differentiated from Dental Pulp Stem Cells, Hinted Crucial Signaling Pathways Promoting Osteogenesis. 

Nováková, S.; Danchenko, M.; Okajčeková, T.; Baranovičová, E.; Kováč, A.; Grendár, M.; Beke, G.; Pálešová, J.; Strnádel, J.; Janíčková, M.; Halašová, E.; Škovierová, H. Int. J. Mol. Sci. 2021, 22, 7908. https://doi.org/10.3390/ijms22157908

The Hsp70–Bag3 complex modulates the phosphorylation and nuclear translocation of Hippo pathway protein Yap.

Simone Baldan, Anatoli B. Meriin, Julia Yaglom, Ilya Alexandrov, Xaralabos Varelas, Zhi-Xiong Jim Xiao, Michael Y. Sherman;  J Cell Sci 1 December 2021; 134 (23): jcs259107. doi: https://doi.org/10.1242/jcs.259107

Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress  
Rebecca L Lloyd, Vaclav Urban, Francisco Muñoz-Martínez, Iñigo Ayestaran, John C Thomas, Christelle de Renty, Mark J O’Connor, Josep V Forment, Yaron Galanty, Stephen P Jackson Nucleic Acids Research gkab628; doi: https://doi.org/10.1093/nar/gkab628

Golgi organization is regulated by proteasomal degradation.
Eisenberg-Lerner, A., Benyair, R., Hizkiahou, N. et al., Nature Communications 11, 409 (2020). https://doi.org/10.1038/s41467-019-14038-9 

The multi-kinase inhibitor lenvatinib interacts with the HDAC inhibitor entinostat to kill liver cancer cells
Jane L. Roberts, Andrew Poklepovic, Laurence Booth, Paul Dent, Cellular Signalling, 2020, 109573, ISSN 0898-6568

Enhanced signaling via ERBB3/PI3K plays a compensatory survival role in pancreatic tumor cells exposed to [neratinib+ valproate]
P Dent, L Booth, A Poklepovic, D Von Hoff, JF Hancock, Cellular Signalling, Jan 2020

Mechanisms of extracellular vesicle uptake in stressed retinal pigment epithelial cell monolayers
C. Nicholson et al., Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, Nov 15 2019

Differences in the Emission of Volatile Organic Compounds (VOCs) between Non-Differentiating and Adipogenically Differentiating Mesenchymal Stromal/Stem Cells from Human Adipose Tissue
Ann-Christin Klemenz et al., Cells 2019, 8(7), 697, 10 July 2019

The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair
Baranes-Bachar et al., Molecular Cell, Volume 69, Issue 5, 1 March 2018, Pages 866-878.e7

Expansion and Antitumor Cytotoxicity of T-Cells Are Augmented by Substrate-Bound CCL21 and Intercellular Adhesion Molecule 1
Adutler-Lieber et al., Front. Immunol., 11 June 2018

The commonly used nonionic surfactant Span 80 has RXRα transactivation activity, which likely increases the obesogenic potential of oil dispersants and food emulsifiers
Bowers RR , Temkin AM , Guillette LJ , Baatz JE , Spyropoulos DD; Gen Comp Endocrinol., 2016 Apr . doi:10.1016/j.ygcen.2016.04.029. PMID: 27131391.
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Registered report: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
Evans J. et al., August 2015, eLife 2015;4:e07301. DOI: 10.7554/eLife.07301
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DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV‐1 infection of macrophages
Petra Mlcochova,* , Sarah J Caswell, Ian A Taylor, Greg J Towers & Ravindra K Gupta, The EMBO Journal, October 2017
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Effects of crude oil/dispersant mixture and dispersant components on PPARγ activity in vitro and in vivo: identification of dioctyl sodium sulfosuccinate (DOSS; CAS #577-11-7) as a probable obesogen.
Temkin AM et al.; Environ Health Perspect, 2016, 124:112–119
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Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species
Jane L. Roberts, Andrew Poklepovic and Laurence Booth, Oncotarget, August 2017
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Nexavar/Stivarga and ViagraInteract to Kill Tumor Cells
Tavalla et al., Journal of Cellular Physiology, 2015, 230: 2281–2298
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PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types
Booth L. et al., Journal of Cellular Physiology, May 2015, Volume 230, Issue 5, pages 1115–1127,
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GRP78 / BiP / HSPA5 / Dna K is a universal therapeutic target for human disease
Booth L. et al.; Journal of Cellular Physiology, 2015, 230(7): 1661-76

Differential regulation of autophagy and cell viability by ceramide species
Nichola Cruickshanks , Jane L Roberts , M Danielle Bareford , Mehrad Tavallai , Andrew Poklepovic , Laurence Booth , Sarah Spiegel , Paul Dent , Cancer Biology & Therapy  Vol. 16, Iss. 5, 2015
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