Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants

Ann-Kathrin Reuschl, Lucy G Thorne, Matthew X.V. Whelan, Roberta Ragazzini, Wilhelm Furnon, Vanessa M Cowton, Giuditta de Lorenzo, Dejan Mesner, Jane E Turner, Giulia Dowgier, Nathasha Bogoda, Paola Bonfanti, Massimo Palmarini, Arvind H Patel, Clare Jolly, Greg J Towers
bioRxiv 2022.07.12.499603; doi: https://doi.org/10.1101/2022.07.12.499603

SARS-CoV-2 Variants Evolve Convergent Strategies to Remodel the Host Response.

 Bouhaddou, Mehdi, et al., Cell (2023) https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4319535

HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells

Ann-Kathrin Reuschl, et al., Cell Reports,Volume 39, Issue 2,2022,110650,ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2022.110650.

Evolution of Resistance to Irinotecan in Cancer Cells Involves Generation of Topoisomerase-Guided Mutations in Non-Coding Genome That Reduce the Chances of DNA Breaks.

Kumar, Santosh, et al. ,International Journal of Molecular Sciences 24.10 (2023): 8717. https://doi.org/10.3390/ijms24108717

A temperature-dependent virus-binding assay reveals the presence of neutralizing antibodies in human cytomegalovirus gB vaccine recipients’ sera.

Gomes, Ariane C., et al. , Journal of General Virology 104.6 (2023): 001860. https://doi.org/10.1099/jgv.0.001860

SARS-CoV-2 evolution influences GBP and IFITM sensitivity

Dejan Mesner,  Ann-Kathrin Reuschl, Matthew V. X. Whelan, +6, and Clare Jolly ; PNAS January 24, 2023, 120 (5) e2212577120 https://doi.org/10.1073/pnas.2212577120

SARS-CoV-2 Spike evolution influences GBP and IFITM sensitivity

Dejan Mesner, Ann-Kathrin Reuschl, Matthew V.X Whelan, Taylor Bronzovich Tafhima Haider1, , Lucy G. Thorne , Greg J. Towers and Clare Jolly, March 2022, bioRxiv preprint doi: https://doi.org/10.1101/2022.03.07.481785

The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread.

Gomes, A.C., Baraniak, I.A., Lankina, A. et al. Nat Commun 14, 1041 (2023). https://doi.org/10.1038/s41467-023-36683-x

Enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants BA.4 and BA.5

HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65

Douglas L. Fink, James Cai, Matthew V. X. Whelan, Christopher Monit, Carlos Maluquer de Motes, Greg J. Towers, Rebecca P. Sumner bioRxiv 2021.06.26.450035; doi: https://doi.org/10.1101/2021.06.26.450035

SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation
Lucy G Thorne, Ann-Kathrin Reuschl, Lorena Zuliani-Alvarez, Matthew V.X. Whelan, View ORCID ProfileMahdad Noursadeghi, Clare Jolly, Greg J Towers
The Embo Journal EMBO J (2021)40:e107826; doi: https://doi.org/10.15252/embj.2021107826

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

Thorne, L.G., Bouhaddou, M., Reuschl, AK. et al., Nature (2021). https://doi.org/10.1038/s41586-021-04352-y

SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation
Lucy G Thorne, Ann-Kathrin Reuschl, Lorena Zuliani-Alvarez, Matthew V.X. Whelan, View ORCID ProfileMahdad Noursadeghi, Clare Jolly, Greg J Towers
The Embo Journal EMBO J (2021)40:e107826; doi: https://doi.org/10.15252/embj.2021107826

Evasion of a human cytomegalovirus entry inhibitor with potent cysteine reactivity is concomitant with the utilization of a heparan sulfate proteoglycan independent route of entry
M.J. Murray, N.I. BonillaMedrano, Q.L. Lee, S.J. Oxenford, R. Angell, D.P. Depledge, M.B. Reeves, Journal of Virology ,Jan 2020, JVI.02012-19; DOI: 10.1128/JVI.02012-19

Evasion of a human cytomegalovirus entry inhibitor with potent cysteine reactivity is concomitant with the utilization of a heparan sulfate proteoglycan independent route of entry
M.J. Murray, N.I. BonillaMedrano, Q.L. Lee, S.J. Oxenford, R. Angell, D.P. Depledge, M.B. Reeves, Journal of Virology ,Jan 2020, JVI.02012-19; DOI: 10.1128/JVI.02012-19

Seronegative patients vaccinated with cytomegalovirus gB-MF59 vaccine have evidence of neutralising antibody responses against gB early post-transplantation
I. Baraniak et al., EBioMedicine, Nov 2019

Dissecting the initial events of human cytomegalovirus cell entry
Matthew James Murray 2019, Doctoral thesis (Ph.D), UCL (University College London), https://discovery.ucl.ac.uk/id/eprint/10079453/

Protection from  cytomegalovirus viremia following glycoprotein B vaccination is not dependent on neutralizing antibodies
Baraniak et al.,PNAS April 23, 2018 

DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV‐1 infection of macrophages
Petra Mlcochova,* , Sarah J Caswell, Ian A Taylor, Greg J Towers & Ravindra K Gupta, The EMBO Journal, October 2017
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A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages
Petra Mlcochova et al., The EMBO Journal, Volume 36, Issue 2 , pp 129 – 244, January 25, 2017
WEB LINK

HIV-1 evades innate immune recognition through specific cofactor recruitment.
Rasaiyaah J. et al.; Nature, 2013 Nov 21;503(7476):402-5
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