Cellular responses after (neratinib plus pemetrexed) exposure in NSCLC cells.

Booth, Laurencea; Poklepovic, Andrewb; Hancock, John F.c; Dent, Paula.Anti-Cancer Drugs 34(9):p 1025-1034, October 2023. | DOI: 10.1097/CAD.0000000000001442 

Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants

Ann-Kathrin Reuschl, Lucy G Thorne, Matthew X.V. Whelan, Roberta Ragazzini, Wilhelm Furnon, Vanessa M Cowton, Giuditta de Lorenzo, Dejan Mesner, Jane E Turner, Giulia Dowgier, Nathasha Bogoda, Paola Bonfanti, Massimo Palmarini, Arvind H Patel, Clare Jolly, Greg J Towers
bioRxiv 2022.07.12.499603; doi: https://doi.org/10.1101/2022.07.12.499603

SARS-CoV-2 Variants Evolve Convergent Strategies to Remodel the Host Response.

 Bouhaddou, Mehdi, et al., Cell (2023) https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4319535

Untersuchung der Effekte Thrombozyten-stämmiger Wachs-tumsfaktoren auf Humane Primärzellen in vitro.


Evolution of Resistance to Irinotecan in Cancer Cells Involves Generation of Topoisomerase-Guided Mutations in Non-Coding Genome That Reduce the Chances of DNA Breaks.

Kumar, Santosh, et al. ,International Journal of Molecular Sciences 24.10 (2023): 8717. https://doi.org/10.3390/ijms24108717

A temperature-dependent virus-binding assay reveals the presence of neutralizing antibodies in human cytomegalovirus gB vaccine recipients’ sera.

Gomes, Ariane C., et al. , Journal of General Virology 104.6 (2023): 001860. https://doi.org/10.1099/jgv.0.001860

Deciphering the involvement of the Hippo pathway co-regulators, YAP/TAZ in invadopodia formation and matrix degradation

Venghateri, J.B., Dassa, B., Morgenstern, D. et al.  Cell Death Dis 14, 290 (2023). https://doi.org/10.1038/s41419-023-05769-1

SARS-CoV-2 evolution influences GBP and IFITM sensitivity

Dejan Mesner,  Ann-Kathrin ReuschlMatthew V. X. Whelan, and Clare Jolly ; PNAS January 24, 2023, 120 (5) e2212577120 https://doi.org/10.1073/pnas.2212577120

Control of human cytomegalovirus replication by liver resident natural killer cells.

Forrest, C., Chase, T.J.G., Cuff, A.O. et al. Nat Commun14, 1409 (2023). https://doi.org/10.1038/s41467-023-37181-w

HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells

Ann-Kathrin Reuschl, et al., Cell Reports,Volume 39, Issue 2,2022,110650,ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2022.110650.

The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread.

Gomes, A.C., Baraniak, I.A., Lankina, A. et al. Nat Commun 14, 1041 (2023). https://doi.org/10.1038/s41467-023-36683-x

 Novel combination of isovanillin, curcumin, and harmine (GZ17-6.02) enhances cell death and alters signaling in actinic keratoses cells when compared to individual components and two-component combinations

Bordeaux, Zachary A.Kwatra, Shawn G.Booth, LaurenceDent, Paul  Anti-Cancer Drugs, Volume 34, Number 4, 18 April 2023, pp. 544-550(7) DOI: https://doi.org/10.1097/CAD.0000000000001425

Enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants BA.4 and BA.5

Ann-Kathrin ReuschlLucy G. ThorneMatthewV.X. WhelanDejan MesnerRoberta RagazziniGiulia DowgierNathasha BogodaJane L. E. TurnerWilhelm FurnonVanessa M. CowtonGiuditta de LorenzoPaola BonfantiMassimo PalmariniArvind H. PatelClare JollyGreg. J. Towers,

Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability

Dan Sarni, Sonia Barroso, Alon Shtrikman, Michal Irony-Tur Sinai, Yifat S. Oren, Andrés Aguilera, Batsheva Kerem, Cell Reports, Volume 40, Issue 13, 2022, 111397, ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2022.111397.

Pericyte derived chemokines amplify neutrophil recruitment across the cerebrovascular endothelial barrier.

Gil E, Venturini C, Stirling D, Turner C, Tezera LB, Ercoli G, Baker T, Best K, Brown JS, Noursadeghi M. Front Immunol. 2022 Jul 28;13:935798. doi: 10.3389/fimmu.2022.935798. PMID: 35967327; PMCID: PMC9371542.

Quantification of Invadopodia Formation and Matrix Degradation Activity.

Venghateri, J.B., Geiger, B. (2023).In: Zaidel-Bar, R. (eds) Mechanobiology. Methods in Molecular Biology, vol 2600. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2851-5_12

Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories.

Bouhaddou M, Reuschl A, Polacco BJ, et al., bioRxiv; 2022. DOI: 10.1101/2022.10.19.512927.

Sensing of Physical Factors by Cells: Electric Field, Mechanical Forces, Physical Plasma and Light—Importance for Tissue Regeneration.

Bielfeldt, M., Rebl, H., Peters, K. et al., Biomedical Materials & Devices (2022). https://doi.org/10.1007/s44174-022-00028-

Golgi screen identifies the RhoGEF Solo as a novel regulator of RhoB and endocytic transport
Cristiana Lungu, Florian Meyer, Marcel Hörning, Jasmin Steudle, Anja Braun, Bettina Noll, David Benz, Felix Fränkle, Simone Schmid, Stephan A. Eisler, Monilola A. Olayioye, December 2022 https://doi.org/10.1111/tra.12880

Integration of the Connectivity Map and Pathway Analysis to Predict Plant Extract’s Medicinal Properties—The Study Case of Sarcopoterium spinosum

Gahramanov, V.; Oz, M.; Aouizerat, T.; Rosenzweig, T.; Gorelick, J.; Drori, E.; Salmon-Divon, M.; Sherman, M.Y.; Lubin, B.C.R.  L. Plants 2022, 11, 2195. https://doi.org/10.3390/plants11172195

Hsp70–Bag3 Module Regulates Macrophage Motility and Tumor Infiltration via Transcription Factor LITAF and CSF1.

Avinery, L.; Gahramanov, V.; Hesin, A.; Sherman, M.Y. Cancers 2022, 14, 4168. https://doi.org/10.3390/cancers14174168

Oxidative Stress Response in Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells

Waheed, Tawakalitu Okikiola, Olga Hahn, Kaarthik Sridharan, Caroline Mörke, Günter Kamp, and Kirsten Peters. 2022 International Journal of Molecular Sciences 23, no. 21: 13435. https://doi.org/10.3390/ijms232113435

Membrane anchored IL-18 linked to constitutively active TLR4 and CD40 improves human T cell antitumor capacities for adoptive cell therapy

Blokon-Kogan D, Levi-Mann M, Malka-Levy L, et al, Journal for ImmunoTherapy of Cancer  2022;10:e001544. doi: 10.1136/jitc-2020-001544

High-throughput screening paradigms in ecotoxicity testing: Emerging prospects and ongoing challenges
Donald Wlodkowic, Marcus Jansen, Chemosphere, Volume 307, Part 2, 2022, 135929, ISSN 0045-6535, https://doi.org/10.1016/j.chemosphere.2022.135929

Deciphering the involvement of the Hippo pathway co-regulators, YAP/TAZ in invadopodia formation and matrix degradation
Jubina Balan Venghateri, Bareket Dassa, David Morgenstern, Michal Shreberk-Shaked, Moshe Oren, Benjamin Geiger
bioRxiv 2022.06.28.497902; doi: https://doi.org/10.1101/2022.06.28.497902

Pneumolysin suppresses the initial macrophage pro-inflammatory response to Streptococcus pneumoniae infection. 

Periselneris, J., Turner, C.T., Ercoli, G., Szylar, G., Weight, C.M., Thurston, T., Whelan, M., Tomlinson, G., Noursadeghi, M. and Brown, J. , Immunology. Accepted Author Manuscript. https://doi.org/10.1111/imm.13546(2022), 

Non-Lytic Egress of Mycobacterium Tuberculosis from Human Macrophages.

Mehta, Meera(2021), Doctoral thesis (Ph.D), UCL (University College London). https://discovery.ucl.ac.uk/id/eprint/10133980/

Cytoplasmic proteotoxicity regulates HRI-dependent phosphorylation of eIF2α via the Hsp70-Bag3 module

Patel, S., Kumar, S., Baldan, S., Hesin, A., Yaglom, J., Sherman, M.Y., ISCIENCE (2022), doi: https://doi.org/10.1016/j.isci.2022.104282.

SARS-CoV-2 Spike evolution influences GBP and IFITM sensitivity

Dejan Mesner, Ann-Kathrin Reuschl, Matthew V.X Whelan, Taylor Bronzovich Tafhima Haider1, , Lucy G. Thorne , Greg J. Towers and Clare Jolly, March 2022, bioRxiv preprint doi: https://doi.org/10.1101/2022.03.07.481785

The GEF-GAP pair Solo and DLC3 balances Rho activity during endocytic transport

C Lungu, F Meyer, M Hörning, J Steudle, A Braun et al., bioRxiv, 2022 bioRxiv preprint doi: https://doi.org/10.1101/2022.03.01.482527

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

Thorne, L.G., Bouhaddou, M., Reuschl, AK. et al., Nature (2021). https://doi.org/10.1038/s41586-021-04352-y

Technologies bringing young zebrafish from a niche field to the limelight
Jason John Otterstrom, Alexandra Lubin, Elspeth Payne, Yael Paran, SLAS Technology, 2022, ISSN 2472-6303, https://doi.org/10.1016/j.slast.2021.12.005.
Effects on mammalian cell transcriptome reveal a plant extract’s medicinal properties: Potential anti-COVID-19 and anti-cancer properties of Sarcopoterium spinosum
M Oz, T Aouizerat, M Salmon-Divon, T Rosenzweig, 2022, Reserach Square, DOI: https://doi.org/10.21203/rs.3.rs-1250188/v1
A novel, dual action chimera comprising DNA methylating agent and near-IR xanthene-cyanine photosensitizer for combined anticancer therapy
Ebaston Thankarajan, Dipak Walunj, Andrii Bazylevich, Chandrashekhar Prasad, Arkadi Hesin, Leonid Patsenker, Gary Gellerman, Photodiagnosis and Photodynamic Therapy, 2022,102722,ISSN 1572-1000, https://doi.org/10.1016/j.pdpdt.2022.102722.
Egr2 induction in spiny projection neurons of the ventrolateral striatum contributes to cocaine place preference in mice
Diptendu Mukherjee, Ben Jerry Gonzales, Reut Ashwal-Fluss, Hagit Turm, Maya Groysman, Ami Citri, eLife 2021;10:e65228 DOI: 10.7554/eLife.65228
Targeted methylation facilitates DNA double strand breaks and enhances cancer suppression: A DNA intercalating/methylating dual-action chimera Amonafidazene
Dipak Walunj, Ebaston Thankarajan, Chandrashekhar Prasad, Helena Tuchinsky, Simone Baldan, Michael Y. Sherman, Leonid Patsenker, Gary Gellerman, European Journal of Medicinal Chemistry, Volume 225, 2021, 113811, ISSN 0223-5234, https://doi.org/10.1016/j.ejmech.2021.113811.
Homologous recombination repair creates mutations in non-coding genome that alter Topoisomerase-1 cleavage sites & orchestrates irinotecan resistance
Santosh KumarValid GahramanovJulia YaglomShivani PatelLukasz KaczmarczykIvan AlexandrovGabi GerlitzMali Salmon-DivonMichael Y. Sherman, bioRxiv 2021.11.26.470089; doi: https://doi.org/10.1101/2021.11.26.470089

The Hsp70–Bag3 complex modulates the phosphorylation and nuclear translocation of Hippo pathway protein Yap.

Simone Baldan, Anatoli B. Meriin, Julia Yaglom, Ilya Alexandrov, Xaralabos Varelas, Zhi-Xiong Jim Xiao, Michael Y. Sherman;  J Cell Sci 1 December 2021; 134 (23): jcs259107. doi: https://doi.org/10.1242/jcs.259107

Genomics and Virulence of Klebsiella pneumoniae Kpnu95 ST1412 Harboring a Novel Incf Plasmid Encoding Blactx-M-15 and Qnrs1 Causing Community Urinary Tract Infection. 

Gancz, A.; Kondratyeva, K.; Cohen-Eli, D.; Navon-Venezia, S. Microorganisms 2021, 9, 1022. https://doi.org/10.3390/microorganisms9051022

eIF2α integrates proteotoxic signals both from ER and cytoplasm: Hsp70-Bag3 module regulates HRI-dependent phosphorylation of eIF2α

Shivani Patel, Santosh Kumar, Arkadi Hesin, Julia Yaglom, Michael Y. Sherman, bioRxiv 2021.04.13.439701; doi: https://doi.org/10.1101/2021.04.13.439701

HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65

Douglas L. Fink, James Cai, Matthew V. X. Whelan, Christopher Monit, Carlos Maluquer de Motes, Greg J. Towers, Rebecca P. Sumner bioRxiv 2021.06.26.450035; doi: https://doi.org/10.1101/2021.06.26.450035

Comparative Proteomic and Metabolomic Analysis of Human Osteoblasts, Differentiated from Dental Pulp Stem Cells, Hinted Crucial Signaling Pathways Promoting Osteogenesis. 

Nováková, S.; Danchenko, M.; Okajčeková, T.; Baranovičová, E.; Kováč, A.; Grendár, M.; Beke, G.; Pálešová, J.; Strnádel, J.; Janíčková, M.; Halašová, E.; Škovierová, H. Int. J. Mol. Sci. 2021, 22, 7908. https://doi.org/10.3390/ijms22157908

The Biocompatibility of Wireless Power Charging System on Human Neural Cells

Henrieta Skovierova 1,*, Miroslav Pavelek 2 , Terezia Okajcekova 3 , Janka Palesova 3 , Jan Strnadel 1 , Pavol Spanik 2 , Erika Halašová 1 and Michal Frivaldsky 2 J. Appl. Sci. 2021, 11, 3611. https://doi.org/10.3390/app11083611

Genomics and Virulence of Klebsiella pneumoniae Kpnu95 ST1412 Harboring a Novel Incf Plasmid Encoding Blactx-M-15 and Qnrs1 Causing Community Urinary Tract Infection. 

Gancz, A.; Kondratyeva, K.; Cohen-Eli, D.; Navon-Venezia, S. Microorganisms 2021, 9, 1022. https://doi.org/10.3390/microorganisms9051022

Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress  
Rebecca L Lloyd, Vaclav Urban, Francisco Muñoz-Martínez, Iñigo Ayestaran, John C Thomas, Christelle de Renty, Mark J O’Connor, Josep V Forment, Yaron Galanty, Stephen P Jackson Nucleic Acids Research gkab628; doi: https://doi.org/10.1093/nar/gkab628

A versatile automated high-throughput drug screening platform for zebrafish embryos
Alexandra LubinJason OtterstromYvette HoadeIvana BjedovEleanor SteadMatthew WhelanGaia GestriYael ParanElspeth Payne
Biology Open 2021.07.09.058513; doi: https://doi.org/10.1242/bio.058513

SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation
Lucy G ThorneAnn-Kathrin ReuschlLorena Zuliani-AlvarezMatthew V.X. WhelanView ORCID ProfileMahdad NoursadeghiClare JollyGreg J Towers
The Embo Journal EMBO J (2021)40:e107826; doi: https://doi.org/10.15252/embj.2021107826

Multi-parametric characterization of drug effects on cells
Paran Y, Liron Y, Batsir S et al. [version 2; peer review: 2 approved]. F1000Research 2021, 9(ISF):1199 (https://doi.org/10.12688/f1000research.26254.2)

The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s. 
Tunbak, H., Enriquez-Gasca, R., Tie, C.H.C. et al. , Nature Communication 11, 5387 (2020). https://doi.org/10.1038/s41467-020-19170-5

Community standards for open cell migration data
Gonzalez-Beltran et al.,  GigaScience, Volume 9, Issue 5, May 2020, giaa041, https://doi.org/10.1093/gigascience/giaa041

TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages
Petra Mlcochova, HelenaWinstone, LorenaZuliani-Alvarez, Ravindra K.Gupta, Cell Reports, Volume 30, Issue 12, 24 March 2020, P 3972-3980.e5

The multi-kinase inhibitor lenvatinib interacts with the HDAC inhibitor entinostat to kill liver cancer cells
Jane L. Roberts, Andrew Poklepovic, Laurence Booth, Paul Dent, Cellular Signalling, 2020, 109573, ISSN 0898-6568

Fingolimod Augments Monomethylfumarate Killing of GBM Cells
Dent Paul, Booth Laurence, Roberts Jane L., Poklepovic Andrew, Hancock John F.,Frontiers in Oncology  vol.10, 2020

(Curcumin+sildenafil) enhances the efficacy of 5FU and anti‐PD1 therapies in vivo.
Dent, P, Booth, L, Roberts, JL, Poklepovic, A, Hancock, JF.,  J Cell Physiol2020; 1– 13. https://doi.org/10.1002/jcp.29580 

Golgi organization is regulated by proteasomal degradation.
Eisenberg-Lerner, A., Benyair, R., Hizkiahou, N. et al., Nature Communications 11, 409 (2020). https://doi.org/10.1038/s41467-019-14038-9 

GZ17‐6.02 initiates DNA damage causing autophagosome‐dependent HDAC degradation resulting in enhanced anti‐PD1 checkpoint inhibitory
Booth, L, Roberts, JL, West, C, Von Hoff, D, Dent, P., J Cell Physiol.,  20201– 16https://doi.org/10.1002/jcp.29464

Evasion of a human cytomegalovirus entry inhibitor with potent cysteine reactivity is concomitant with the utilisation of a heparan sulfate proteoglycan independent route of entry
M.J. MurrayN.I. BonillaMedranoQ.L. LeeS.J. OxenfordR. AngellD.P. DepledgeM.B. Reeves, Journal of Virology ,Jan 2020, JVI.02012-19; DOI: 10.1128/JVI.02012-19

Enhanced signaling via ERBB3/PI3K plays a compensatory survival role in pancreatic tumor cells exposed to [neratinib+ valproate]
P Dent, L Booth, A Poklepovic, D Von Hoff, JF Hancock, Cellular Signalling, Jan 2020‏

Seronegative patients vaccinated with cytomegalovirus gB-MF59 vaccine have evidence of neutralising antibody responses against gB early post-transplantation
I. Baraniak et al., EBioMedicine, Nov 2019

Mechanisms of extracellular vesicle uptake in stressed retinal pigment epithelial cell monolayers
C. Nicholson et al., Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, Nov 15 2019

Dissecting the initial events of human cytomegalovirus cell entry
Matthew James Murray 2019, Doctoral thesis (Ph.D), UCL (University College London), https://discovery.ucl.ac.uk/id/eprint/10079453/

Regorafenib Enhances Lethality of Sildenafil and Curcumin in Colorectal Cancer Cells
KB Owusu, M Director, P Dent , VCU THESES AND DISSERTATIONS, Feb 2019‏

Differences in the Emission of Volatile Organic Compounds (VOCs) between Non-Differentiating and Adipogenically Differentiating Mesenchymal Stromal/Stem Cells from Human Adipose Tissue
Ann-Christin Klemenz et al., Cells 2019, 8(7), 697, 10 July 2019

Cooperativity between stromal cytokines drives the invasive migration of human breast cancer cells
Y Elisha et al., The Royal Society Volume 374, Issue 1779, 01 July 2019

Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells
P Dent et al., Oncogene (2019)

IFN-independent G0 arrest and SAMHD1 activation following TLR4 activation in macrophages
P. Mlcochova, H. Winstone, L. Zuliani-Alvarez, R.K. Gupta, bioRxiv 741124

Palbociclib augments Neratinib killing of tumor cells that is further enhanced by HDAC inhibition
L Booth et al., Cancer Biology &Therapy, 5 September 2018

The CHK1 inhibitor SRA737 synergizes with PARP1 inhibitors to kill carcinoma cells
Laurence Booth, Jane Roberts, Andrew Poklepovic & Paul Dent, Cancer Biology & Therapy, 19 July 2018

Expansion and Antitumor Cytotoxicity of T-Cells Are Augmented by Substrate-Bound CCL21 and Intercellular Adhesion Molecule 1
Adutler-Lieber et al., Front. Immunol., 11 June 2018

Valproate augments Niraparib killing of tumor cells
Laurence Booth et al., Cancer biol ther., June 2018

Protection from  cytomegalovirus viremia following glycoprotein B vaccination is not dependent on neutralizing antibodies
Baraniak et al.,PNAS April 23, 2018 

The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair
Baranes-Bachar et al., Molecular Cell, Volume 69, Issue 5, 1 March 2018, Pages 866-878.e7

TP53 is required for BECN1-and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition
Santiago Lima et al., Autophagy, Jan 25, 2018

[Neratinib + Valproate] exposure permanently reduces ERBB1 and RAS expression in 4T1 mammary tumors and enhances M1 macrophage infiltration.
Booth et al., Oncotarget, 26;9(5):6062-6074, Dec 2017

The levels of mutant K-RAS and mutant N-RAS are rapidly reduced in a Beclin1 / ATG5 -dependent fashion by the irreversible ERBB1/2/4 inhibitor neratinib
Laurence Booth t al., Cancer biology & therapy, volume 19, issue 2, 2018

Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species
Jane L. Roberts, Andrew Poklepovic and Laurence Booth, Oncotarget, August 2017

DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV‐1 infection of macrophages
Petra Mlcochova,* , Sarah J Caswell, Ian A Taylor, Greg J Towers & Ravindra K Gupta, The EMBO Journal, October 2017

Substrate-bound CCL21 and ICAM1 combined with soluble IL-6 collectively augment the expansion of antigen-specific murine CD4+ T cells
Shimrit Adutler-Lieber, et al., Blood Advances Journal, Volume 1, Issue 15, pp 1016-1030, May 13, 2017

A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages
Petra Mlcochova et al., The EMBO Journal, Volume 36, Issue 2 , pp 129 – 244, January 25, 2017

PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide
Laurence Booth, Jane L. Roberts, Andrew Poklepovic, Sarah Gordon, Paul Dent, Impactjournals- Oncotarget, Advance Publications 2016, November 2016, changes 5: 9

Lipopolysaccharide induces proliferation and osteogenic differentiation of adipose-derived mesenchymal stromal cells in vitro via TLR4 activation
Nicole Herzmann, Achim Salamon, Tomas Fiedler and Kirsten Peters, Experimental Cell Research, https://dx.doi.org/10.1016/j.yexcr.2016.11.012

The commonly used nonionic surfactant Span 80 has RXRα transactivation activity, which likely increases the obesogenic potential of oil dispersants and food emulsifiers
Bowers RR , Temkin AM , Guillette LJ , Baatz JE , Spyropoulos DD; Gen Comp Endocrinol., 2016 Apr . doi:10.1016/j.ygcen.2016.04.029. PMID: 27131391.

Rationally repurposing Ruxolitinib (Jakafi®) as a solid tumor therapeutic
Tavallai Mehrad, Booth Laurence, Roberts Jane L, Poklepovic Andrew, Dent Paul ; Frontiers in Oncology, vol.6,2016

Effects of crude oil/dispersant mixture and dispersant components on PPARγ activity in vitro and in vivo: identification of dioctyl sodium sulfosuccinate (DOSS; CAS #577-11-7) as a probable obesogen.
Temkin AM et al.; Environ Health Perspect, 2016, 124:112–119

Nexavar/Stivarga and ViagraInteract to Kill Tumor Cells
Tavalla et al., Journal of Cellular Physiology, 2015, 230: 2281–2298

PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types
Booth L. et al., Journal of Cellular Physiology, May 2015, Volume 230, Issue 5, pages 1115–1127,

Registered report: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
Evans J. et al., August 2015, eLife 2015;4:e07301. DOI: 10.7554/eLife.07301

GRP78 / BiP / HSPA5 / Dna K is a universal therapeutic target for human disease
Booth L. et al.; Journal of Cellular Physiology, 2015, 230(7): 1661-76

Differential regulation of autophagy and cell viability by ceramide species
Nichola Cruickshanks , Jane L Roberts , M Danielle Bareford , Mehrad Tavallai , Andrew Poklepovic , Laurence Booth , Sarah Spiegel , Paul Dent , Cancer Biology & Therapy  Vol. 16, Iss. 5, 2015

Variomics screen identifies the reentrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation
Bill A. et al.;  Journal of Biological Chemistry, 2015, 290: 889-903

High-throughput fluorescence imaging approaches for drug discovery using in vitro and in vivo three-dimensional models
Natalia J Martinez , Steven A Titus , Amanda K Wagner , Anton Simeonov , Expert Opinion on Drug Discovery Vol. 10, Iss. 12, 2015

Celecoxib enhances [sorafenib + sildenafil] lethality in cancer cells and reverts platinum chemotherapy resistance
Timothy Webb , Jori Carter , Jane L Roberts , Andrew Poklepovic , William P McGuire , Laurence Booth , Paul Dent , Cancer Biology & Therapy  Vol. 16, Iss. 11, 2015

3,5-Diamino-1,3,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors
Kutz CJ. Et al.; Medicinal Chemistry Communications, 2014, 5, 1863-1870

Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs
Booth L. et al.; Mol Cancer Ther, October 2014, 13; 2384

The Cofilin Phosphatase Slingshot Homolog 1 (SSH1) Links NOD1 Signaling to Actin Remodeling
Bielig H. et al.; PLOS Pathogens, 2014, 10, 9.

Soft/elastic nanopatterned biointerfaces in the service of cell biology
Platzman l. et al.; METHODS IN CELL BIOLOGY; 2014, 119:237-260

HIV-1 evades innate immune recognition through specific cofactor recruitment.
Rasaiyaah J. et al.; Nature, 2013 Nov 21;503(7476):402-5

Regulation of Integrin Adhesions by Varying the Density of Substrate-Bound Epidermal Growth Factor
Shahal T. et al.; Biointerphases  ,2012, Volume 7, Issue 1

High content imaging (HCI), is a powerful image-based paradigm used across the full spectrum of biochemistry, cellular biology, microbiology, molecular biology, drug discovery, and more. The primary thrust of high content imaging platforms is the extraction of high content data from an image of a biological sample.  The ‘content’ in the data includes information such as size, shape, color, quantity, brightness and relative or absolute location. Many different types of imaging systems could be described as high content – but there are key details to bear in mind.