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Type I interferon responses contribute to immune protection against mycobacterial infection. Szydlo-Shein, A., Sanz-Magallón Duque de Estrada, B., Rosenheim, J., Turner, C.T., Tsaliki, E., Lipman, M.C., Kunst, H., Pollara, G., Elks, P.M., Levraud, J.P. and Payne, E.M., medRxiv, pp.2024-06, 2024.

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The Triterpenoid MOMORDIN-Ic Inhibits HCMV by Preventing the Initiation of Gene Expression in Eukaryotic Cells. Bradley E, Poole E, Reeves MB. Pathogens. 2024; 13(7):546. https://doi.org/10.3390/pathogens13070546

Cold Atmospheric Pressure Plasma-Activated Medium Modulates Cellular Functions of Human Mesenchymal Stem/Stromal Cells In Vitro. Hahn, O., Waheed, T.O., Sridharan, K., Huemerlehner, T., Staehlke, S., Thürling, M., Boeckmann, L., Meister, M., Masur, K. and Peters, K., 2024. International Journal of Molecular Sciences25(9), p.4944. Int. J. Mol. Sci. 202425(9), 4944; https://doi.org/10.3390/ijms25094944

A high-throughput zebrafish screen identifies novel candidate treatments for Kaposiform Lymphangiomatosis (KLA). Bassi, I., Jabali, A., Farag, N., Egozi, S., Moshe, N., Leichner, G.S., Geva, P., Levin, L., Barzilai, A., Avivi, C. and Long, J., 2024. bioRxiv, pp.2024-03. doi: https://doi.org/10.1101/2024.03.21.586124

Comparison of pulsed and continuous electromagnetic field generated by WPT system on human dermal and neural cells. Zahumenska, R., Badurova, B., Pavelek, M. et al.Sci Rep 14, 5514 (2024). https://doi.org/10.1038/s41598-024-56051-z

5, 6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP3 signaling pathway. Asulin, M., Gorodetzer, N., Fridman, R., Ben-Shushan, R.S., Cohen, Z., Beyer, A.M., Chuyun, D., Gutterman, D.D. and Szuchman-Sapir, A Biochemical and Biophysical Research Communications,2024 p.149585.

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Learning Dynamics from Multicellular Graphs with Deep Neural Networks. Yang, H., Meyer, F., Huang, S., Yang, L., Lungu, C., Olayioye, M.A., Buehler, M.J. and Guo, M., 2024. arXiv preprint arXiv:2401.12196

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Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants. Reuschl, AK., Thorne, L.G., Whelan, M.V.X. et al. Nature Microbiology (2024). https://doi.org/10.1038/s41564-023-01588-4

GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells. Booth, M.R., Booth, L., Roberts, J.L., West, C. and Dent, P., 2024.  Oncotarget15, p.124. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852062/

Repression of the major immediate early promoter of human cytomegalovirus allows transcription from an alternate promoter.  Mason, R., Bradley, E., Wills, M., Sinclair, J. and Reeves, M., 2023. Journal of General Virology, 104(9), p.001894. https://doi.org/10.1099/jgv.0.001894

Cellular Responses after (Neratinib Plus Pemetrexed) Exposure in NSCLC Cells. Booth, Laurence; Poklepovic, Andrew; Hancock, John F.; Dent, Paula. Anti-Cancer Drugs, 34(9), 1025-1034, October 2023. DOI: 10.1097/CAD.0000000000001442

SARS-CoV-2 Variants Evolve Convergent Strategies to Remodel the Host Response. Bouhaddou, Mehdi, et al. Cell (2023) Web link

Automated, High-throughput Quantification of EGFP-expressing Neutrophils in Zebrafish by Machine Learning and a Highly-parallelized Microscope. Efromson J, Ferrero G, Bègue A, Doman TJJ, Dugo C, Barker A, Saliu V, Reamey P, Kim K, Harfouche M, Yoder JA. bioRxiv [Preprint]. 2023 Aug 18:2023.08.16.553550. DOI: 10.1101/2023.08.16.553550

Untersuchung der Effekte Thrombozyten-stämmiger Wachstumsfaktoren auf Humane Primärzellen in vitro. ROSTOCK, UNIVERSITÄTSMEDIZIN. [Web link]

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Evolution of Resistance to Irinotecan in Cancer Cells Involves Generation of Topoisomerase-Guided Mutations in Non-Coding Genome That Reduce the Chances of DNA Breaks. Kumar, Santosh, et al. International Journal of Molecular Sciences, 24(10), 8717, 2023. DOI: 10.3390/ijms24108717

A Temperature-dependent Virus-binding Assay Reveals the Presence of Neutralizing Antibodies in Human Cytomegalovirus gB Vaccine Recipients’ Sera. Gomes, Ariane C., et al. Journal of General Virology, 104(6), 001860, 2023. DOI: 10.1099/jgv.0.001860

Deciphering the Involvement of the Hippo Pathway Co-regulators, YAP/TAZ in Invadopodia Formation and Matrix Degradation. Venghateri, J.B., Dassa, B., Morgenstern, D. et al. Cell Death & Disease, 14, 290, 2023. DOI: 10.1038/s41419-023-05769-1

Development of a versatile, automated and high-throughput drug screening platform for zebrafish embryos to find novel therapeutics for AML
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SARS-CoV-2 Evolution Influences GBP and IFITM Sensitivity
Dejan Mesner, Ann-Kathrin Reuschl, Matthew V. X. Whelan, +6, and Clare Jolly
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Control of Human Cytomegalovirus Replication by Liver Resident Natural Killer Cells
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HIV-1 Vpr Drives a Tissue Residency-Like Phenotype During Selective Infection of Resting Memory T Cells
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The Cytomegalovirus gB/MF59 Vaccine Candidate Induces Antibodies Against an Antigenic Domain Controlling Cell-to-Cell Spread
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Novel Combination of Isovanillin, Curcumin, and Harmine (GZ17-6.02) Enhances Cell Death and Alters Signaling in Actinic Keratoses Cells When Compared to Individual Components and Two-Component Combinations
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Enhanced Innate Immune Suppression by SARS-CoV-2 Omicron Subvariants BA.4 and BA.5
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Topoisomerase 1-Dependent R-loop Deficiency Drives Accelerated Replication and Genomic Instability
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Pericyte Derived Chemokines Amplify Neutrophil Recruitment Across the Cerebrovascular Endothelial Barrier
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Sensing of Physical Factors by Cells: Electric Field, Mechanical Forces, Physical Plasma and Light—Importance for Tissue Regeneration
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Golgi Screen Identifies the RhoGEF Solo as a Novel Regulator of RhoB and Endocytic Transport
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Integration of the Connectivity Map and Pathway Analysis to Predict Plant Extract’s Medicinal Properties—The Study Case of Sarcopoterium spinosum
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Hsp70–Bag3 Module Regulates Macrophage Motility and Tumor Infiltration via Transcription Factor LITAF and CSF1
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Oxidative Stress Response in Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells
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Membrane Anchored IL-18 Linked to Constitutively Active TLR4 and CD40 Improves Human T Cell Antitumor Capacities for Adoptive Cell Therapy
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High-Throughput Screening Paradigms in Ecotoxicity Testing: Emerging Prospects and Ongoing Challenges
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Deciphering the Involvement of the Hippo Pathway Co-Regulators, YAP/TAZ in Invadopodia Formation and Matrix Degradation
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Pneumolysin Suppresses the Initial Macrophage Pro-Inflammatory Response to Streptococcus Pneumoniae Infection
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Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity. Sorek, M., Oweis, W., Nissim-Rafinia, M. et al.; Genome Biol 22, 73 (2021). https://doi.org/10.1186/s13059-021-02301-6

Non-Lytic Egress of Mycobacterium Tuberculosis from Human Macrophages
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Cytoplasmic Proteotoxicity Regulates HRI-Dependent Phosphorylation of eIF2α via the Hsp70-Bag3 Module
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SARS-CoV-2 Spike Evolution Influences GBP and IFITM Sensitivity
Dejan Mesner, Ann-Kathrin Reuschl, Matthew V.X Whelan, Taylor Bronzovich Tafhima Haider1, Lucy G. Thorne, Greg J. Towers, and Clare Jolly
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The GEF-GAP Pair Solo and DLC3 Balances Rho Activity During Endocytic Transport
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Evolution of Enhanced Innate Immune Evasion by the SARS-CoV-2 B.1.1.7 UK Variant
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Technologies Bringing Young Zebrafish from a Niche Field to the Limelight
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Effects on Mammalian Cell Transcriptome Reveal a Plant Extract’s Medicinal Properties: Potential Anti-COVID-19 and Anti-Cancer Properties of Sarcopoterium spinosum
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A Novel, Dual-Action Chimera Comprising DNA Methylating Agent and Near-IR Xanthene-Cyanine Photosensitizer for Combined Anticancer Therapy
Ebaston Thankarajan, Dipak Walunj, Andrii Bazylevich, Chandrashekhar Prasad, Arkadi Hesin, Leonid Patsenker, Gary Gellerman
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Egr2 Induction in Spiny Projection Neurons of the Ventrolateral Striatum Contributes to Cocaine Place Preference in Mice
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Targeted Methylation Facilitates DNA Double-Strand Breaks and Enhances Cancer Suppression: A DNA Intercalating/Methylating Dual-Action Chimera Amonafidazene
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Homologous Recombination Repair Creates Mutations in Non-Coding Genome That Alter Topoisomerase-1 Cleavage Sites & Orchestrates Irinotecan Resistance
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The Hsp70–Bag3 Complex Modulates the Phosphorylation and Nuclear Translocation of Hippo Pathway Protein Yap
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Genomics and Virulence of Klebsiella pneumoniae Kpnu95 ST1412 Harboring a Novel Incf Plasmid Encoding Blactx-M-15 and Qnrs1 Causing Community Urinary Tract Infection
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eIF2α Integrates Proteotoxic Signals Both from ER and Cytoplasm: Hsp70-Bag3 Module Regulates HRI-Dependent Phosphorylation of eIF2α
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HIV-2/SIV Vpx Antagonises NF-κB Activation by Targeting p65
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Comparative Proteomic and Metabolomic Analysis of Human Osteoblasts, Differentiated from Dental Pulp Stem Cells, Hinted Crucial Signaling Pathways Promoting Osteogenesis
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The Biocompatibility of Wireless Power Charging System on Human Neural Cells
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Genomics and Virulence of Klebsiella pneumoniae Kpnu95 ST1412 Harboring a Novel Incf Plasmid Encoding Blactx-M-15 and Qnrs1 Causing Community Urinary Tract Infection
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Loss of Cyclin C or CDK8 Provides ATR Inhibitor Resistance by Suppressing Transcription-Associated Replication Stress
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A Versatile Automated High-Throughput Drug Screening Platform for Zebrafish Embryos
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SARS-CoV-2 Sensing by RIG-I and MDA5 Links Epithelial Infection to Macrophage Inflammation
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Multi-Parametric Characterization of Drug Effects on Cells
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The HUSH Complex Is a Gatekeeper of Type I Interferon Through Epigenetic Regulation of LINE-1s
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GZ17‐6.02 Initiates DNA Damage Causing Autophagosome‐dependent HDAC Degradation Resulting in Enhanced Anti-PD1 Checkpoint Inhibitory
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Evasion of a Human Cytomegalovirus Entry Inhibitor with Potent Cysteine Reactivity Is Concomitant with the Utilization of a Heparan Sulfate Proteoglycan Independent Route of Entry
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Enhanced Signaling via ERBB3/PI3K Plays a Compensatory Survival Role in Pancreatic Tumor Cells Exposed to [Neratinib+ Valproate]
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Seronegative Patients Vaccinated with Cytomegalovirus gB-MF59 Vaccine Have Evidence of Neutralizing Antibody Responses Against gB Early Post-Transplantation
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Dissecting the Initial Events of Human Cytomegalovirus Cell Entry
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Regorafenib Enhances Lethality of Sildenafil and Curcumin in Colorectal Cancer Cells
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Differences in the Emission of Volatile Organic Compounds (VOCs) between Non-Differentiating and Adipogenically Differentiating Mesenchymal Stromal/Stem Cells from Human Adipose Tissue
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IFN-Independent G0 Arrest and SAMHD1 Activation Following TLR4 Activation in Macrophages
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Palbociclib Augments Neratinib Killing of Tumor Cells That Is Further Enhanced by HDAC Inhibition
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The CHK1 Inhibitor SRA737 Synergizes with PARP1 Inhibitors to Kill Carcinoma Cells
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Valproate Augments Niraparib Killing of Tumor Cells
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The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair
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TP53 Is Required for BECN1- and ATG5-Dependent Cell Death Induced by Sphingosine Kinase 1 Inhibition
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DNA Damage Induced by Topoisomerase Inhibitors Activates SAMHD1 and Blocks HIV‐1 Infection of Macrophages
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A G1-Like State Allows HIV-1 to Bypass SAMHD1 Restriction in Macrophages
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The EMBO Journal Volume 36, Issue 2 , pp 129 – 244, January 25, 2017
[WEB LINK]

PDE5 Inhibitors Enhance the Lethality of Pemetrexed Through Inhibition of Multiple Chaperone Proteins and Via the Actions of Cyclic GMP and Nitric Oxide
Laurence Booth, Jane L. Roberts, Andrew Poklepovic, Sarah Gordon, Paul Dent
Impact Journals – Oncotarget Advance Publications 2016, November 2016, Changes 5: 9
[WEB LINK]

Lipopolysaccharide Induces Proliferation and Osteogenic Differentiation of Adipose-Derived Mesenchymal Stromal Cells In Vitro via TLR4 Activation
Nicole Herzmann, Achim Salamon, Tomas Fiedler, and Kirsten Peters
Experimental Cell Research DOI:10.1016/j.yexcr.2016.11.012

The Commonly Used Nonionic Surfactant Span 80 Has RXRα Transactivation Activity, Which Likely Increases the Obesogenic Potential of Oil Dispersants and Food Emulsifiers
Bowers RR, Temkin AM, Guillette LJ, Baatz JE, Spyropoulos DD
Gen Comp Endocrinol. 2016 Apr. doi:10.1016/j.ygcen.2016.04.029. PMID: 27131391
[WEB LINK]

Rationally Repurposing Ruxolitinib (Jakafi®) as a Solid Tumor Therapeutic
Tavallai Mehrad, Booth Laurence, Roberts Jane L, Poklepovic Andrew, Dent Paul
Frontiers in Oncology vol.6, 2016
[WEB LINK]

Effects of Crude Oil/Dispersant Mixture and Dispersant Components on PPARγ Activity In Vitro and In Vivo: Identification of Dioctyl Sodium Sulfosuccinate (DOSS; CAS #577-11-7) as a Probable Obesogen
Temkin AM et al.
Environ Health Perspect 2016, 124:112–119
[WEB LINK]

Nexavar/Stivarga and Viagra Interact to Kill Tumor Cells
Tavalla et al.
Journal of Cellular Physiology 2015, 230: 2281–2298
[WEB LINK]

PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types
Booth L. et al.
Journal of Cellular Physiology May 2015, Volume 230, Issue 5, pages 1115–1127
[WEB LINK](URL not provided)

Registered Report: Wnt Activity Defines Colon Cancer Stem Cells and Is Regulated by the Microenvironment
Evans J. et al.
eLife 2015;4:e07301. DOI: 10.7554/eLife.07301
[WEB LINK]

GRP78 / BiP / HSPA5 / Dna K Is a Universal Therapeutic Target for Human Disease
Booth L. et al.
Journal of Cellular Physiology 2015, 230(7): 1661-76
[WEB LINK]

Differential Regulation of Autophagy and Cell Viability by Ceramide Species
Nichola Cruickshanks , Jane L Roberts , M Danielle Bareford , Mehrad Tavallai , Andrew Poklepovic , Laurence Booth , Sarah Spiegel , Paul Dent
Cancer Biology & Therapy Vol. 16, Iss. 5, 2015
[WEB LINK]

Variomics Screen Identifies the Reentrant Loop of the Calcium-Activated Chloride Channel ANO1 That Facilitates Channel Activation
Bill A. et al.
Journal of Biological Chemistry 2015, 290: 889-903
[WEB LINK]

High-Throughput Fluorescence Imaging Approaches for Drug Discovery Using In Vitro and In Vivo Three-Dimensional Models
Natalia J Martinez , Steven A Titus , Amanda K Wagner , Anton Simeonov
Expert Opinion on Drug Discovery Vol. 10, Iss. 12, 2015
[WEB LINK]

Celecoxib Enhances [Sorafenib + Sildenafil] Lethality in Cancer Cells and Reverts Platinum Chemotherapy Resistance
Timothy Webb , Jori Carter , Jane L Roberts , Andrew Poklepovic , William P McGuire , Laurence Booth , Paul Dent
Cancer Biology & Therapy Vol. 16, Iss. 11, 2015
[WEB LINK]

Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs
Booth L. et al.
Molecular Cancer Therapeutics October 2014, 13; 2384
[WEB LINK]

The Cofilin Phosphatase Slingshot Homolog 1 (SSH1) Links NOD1 Signaling to Actin Remodeling
Bielig H. et al.
PLOS Pathogens 2014, 10, 9
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Soft/Elastic Nanopatterned Biointerfaces in the Service of Cell Biology
Platzman l. et al.
Methods in Cell Biology 2014, 119:237-260
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HIV-1 Evades Innate Immune Recognition Through Specific Cofactor Recruitment
Rasaiyaah J. et al.
Nature 2013 Nov 21;503(7476):402-5
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Regulation of Integrin Adhesions by Varying the Density of Substrate-Bound Epidermal Growth Factor
Shahal T. et al.
Biointerphases 2012, Volume 7, Issue 1
[WEB LINK]

High content imaging (HCI), is a powerful image-based paradigm used across the full spectrum of biochemistry, cellular biology, microbiology, molecular biology, drug discovery, and more. The primary thrust of high content imaging platforms is the extraction of high content data from an image of a biological sample.  The ‘content’ in the data includes information such as size, shape, color, quantity, brightness and relative or absolute location. Many different types of imaging systems could be described as high content – but there are key details to bear in mind.